Publications
TCNH multidisciplinary staff are committed to training of the next generation of neonatal healthcare practitioners. Take a look at some of their recent contributions to the field.
Neonatology in Review
Metabolic acidosis during continuous glucagon therapy for neonatal hypoglycemia
Hoban, R., Tomlinson, C., Chung, E., Mann, J.
Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation
Koike Y, Li B, Ganji N, Zhu H, Miyake H, Chen Y, Lee C, Janssen Lok M, Zozaya C, Lau E, Lee D, Chusilp S, Zhang Z, Yamoto M, Wu RY, Inoue M, Uchida K, Kusunoki M, Delgado-Olguin P, Mertens L, Daneman A, Eaton S, Sherman PM, Pierro A.
Percutaneous Closure of Patent Ductus Arteriosus in Infants 1.5 kg or Less: A Meta-Analysis
Bischoff AR, Jasani B, Sathanandam SK, Backes C, Weisz DE, McNamara PJ.
Percutaneous Closure of Patent Ductus Arteriosus in Infants 1.5 kg or Less: A Meta-Analysis
Bischoff AR, Jasani B, Sathanandam SK, Backes C, Weisz DE, McNamara PJ. Percutaneous Closure of Patent Ductus Arteriosus in Infants 1.5 kg or Less: A Meta-Analysis. J Pediatr. 2020 Oct 22:S0022-3476(20)31307-X. doi: 10.1016/j.jpeds.2020.10.035. Epub ahead of print. PMID: 33098843.
Neonatal Neurology
Click the button below to read more about work from our Neurology colleagues in neonatal and neurocritical care.
Abnormalities in evoked potentials associated with abnormal glycemia and brain injury in neonatal hypoxic-ischemic encephalopathy
Kamino D, Almazrooei A, Pang EW, Widjaja E, Moore AM, Chau V, Tam EWY. Abnormalities in evoked potentials associated with abnormal glycemia and brain injury in neonatal hypoxic-ischemic encephalopathy. Clin Neurophysiol. 2020 Oct 22:S1388-2457(20)30506-X. doi: 10.1016/j.clinph.2020.09.024. Epub ahead of print. PMID: 33158762.
Highlights
- • Maximal but not minimal glucose is associated with atypical VEPs in neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE).
- • Minimal but not maximal glucose is associated with atypical SEPs in neonates treated with therapeutic hypothermia for HIE.
- • Postnatally, VEPs can predict the presence of brain injury in the visual processing pathway via MRI in cooled neonates with HIE.
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The Effect of Music and White Noise on Electroencephalographic (EEG) Functional Connectivity in Neonates in the Neonatal Intensive Care Unit
Akiyama A, Tsai JD, W Y Tam E, Kamino D, Hahn C, Go CY, Chau V, Whyte H, Wilson D, McNair C, Papaioannou V, Hugh SC, Papsin BC, Nishijima S, Yamazaki T, Miller SP, Ochi A. The Effect of Music and White Noise on Electroencephalographic (EEG) Functional Connectivity in Neonates in the Neonatal Intensive Care Unit. J Child Neurol. 2021 Jan;36(1):38-47. doi: 10.1177/0883073820947894. Epub 2020 Aug 24. PMID: 32838628.
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The Response to Stress Questionnaire for Parents Following Neonatal Brain Injury
McDonald, K.P., Connolly, J., Roberts, S.D., Ford, M.K., Westmacott, R., Dlamini, N., Tam, E.W. and Williams, T., 2020. The Response to Stress Questionnaire for Parents Following Neonatal Brain Injury. Journal of Pediatric Psychology, 45(9), pp.1005-1015.
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Location and Size of Preterm Cerebellar Hemorrhage and Childhood Development
Garfinkle, J., Guo, T., Synnes, A., Chau, V., Branson, H.M., Ufkes, S., Tam, E.W.Y., Grunau, R.E. and Miller, S.P. (2020), Location and Size of Preterm Cerebellar Hemorrhage and Childhood Development. Ann Neurol, 88: 1095-1108. https://doi.org/10.1002/ana.25899
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Mechanical Ventilation Duration, Brainstem Development, and Neurodevelopment in Children Born Preterm: A Prospective Cohort Study
Guillot M, Guo T, Ufkes S, Schneider J, Synnes A, Chau V, Grunau RE, Miller SP. Mechanical Ventilation Duration, Brainstem Development, and Neurodevelopment in Children Born Preterm: A Prospective Cohort Study. J Pediatr. 2020 May 23:S0022-3476(20)30653-3. doi: 10.1016/j.jpeds.2020.05.039. Epub ahead of print. PMID: 32454115.
Nursing Education
Nurses are a vital part of any clinical team, and are often the leaders and drivers of change. Click the link below to read recent award winning articles from the SickKids Neonatal Nurse Practitioners who have been named the 2020 recipients of the Neonatal Network Excellence in Writing Award, as well as the Manuscript of Exceptional Merit Award,
Special Edition:
Neonatal Network May/June 2020
The SickKids Neonatal Nurse Practitioners have recently written articles to comprise a special edition of the peer-reviewed nursing journal, Neonatal Network.
As the sole contributors to the full May/June 2020 edition, and given the diverse and rich expertise they have developed through the complex patient population at SickKids, those chose 5 different subtopics to develop the theme of neonatal neurocritical care.
The Neonatal Neurological Examination: Improving Understanding and Performance
**WINNERS of the 2020 Neonatal Network Excellence in Writing Award**
Judith Hawes, MN, RN(EC) NP-Paediatrics, NNP-BC
Stephanie Bernardo, MN, RN(EC) NP-Paediatrics
Diane Wilson, MN, RN(EC) NP-Paediatrics, NNP-BC
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From Sacrum to Spine: A Complex Case of Sacrococcygeal Teratoma
**WINNERS of the 2020 Manuscript of Exceptional Merit award**
Jennifer Young, MN, RN(EC) NP-Pediatrics, NNP-BC
Hazel Pleasants-Terashita, MN, RN(EC) NP-Pediatrics, NNP-BC
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Sharing Knowledge to Enhance Neonatal Neurocritical Care
Diane Wilson, MN, RN(EC) NP-Pediatrics, NNP-BC
Jennifer Young, MN, RN(EC) NP-Pediatrics, NNP-BC
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Glucose Homeostasis and the Neonatal Brain: A Sweet Relationship
Stephanie Amendoeira, RN(EC), MN, NP-Pediatrics, NNP-Dip
Carol McNair, RN(EC), MN, PhD(c), NNP-BC, NP-Pediatrics
Jennie Saini, RN(EC), MN, NP-Pediatrics, NNP-Dip
Sharifa Habib, RN(EC), MN, NP-Pediatrics, NNP-Dip
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Hemodynamic Instability in Hypoxic Ischemic Encephalopathy: More Than Just Brain Injury—Understanding Physiology, Assessment, and Management
Sharifa Habib, RN(EC), MN, NP-Pediatrics, NNP-Dip
Jennie Saini, RN(EC), MN, NP-Pediatrics, NNP-Dip
Stephanie Amendoeira, RN(EC), MN, NP-Pediatrics, NNP-Dip
Carol McNair, RN(EC), MN, PhD(c), NNP-BC, NP-Pediatrics
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Intraventricular Hemorrhage and Post-hemorrhagic Ventricular Dilation: Current Approaches to Improve Outcomes
Diane Wilson, MN, RN(EC) NP-Pediatrics, NNP-BC
Kim Dionne, MN, RN(EC) NP-Pediatrics, NNP-BC
Sara Breibart, MN, RN(EC) NP-Pediatrics
TCNH Fellows
The TCNH takes pride in their trainees. Take a look at recent publications and presentations from our various Departmental, Royal College, Transport, Neurology, Hemodynamics, and Research fellows.
2023
Elkhouli M, Aleali F, Alzamrooni A, Chiu P, Gauda EB. Ileal lactobezoar in an extreme premature infant complicated by intestinal perforation: A case report
2022
Mohsen N, Nasef N, Elkhouli M, Ghanem M, Dalby A, Yoon EW, Finan E, Shah PS, Mohamed A. Predictors of Successful Trial off Continuous Positive Airway Pressure and High Flow Nasal Cannula in Preterm Infants < 30 weeks gestation: A Retrospective Study. Pediatr Pulmonol. 2022 Jan 15. doi: 10.1002/ppul.25827
Mohamed A, Mohsen N, Diambomba Y, Lashin A, Louis D, Elsayed Y, Shah PS. Lung Ultrasound for Prediction of Bronchopulmonary Dysplasia in Extreme Preterm Neonates: A Prospective Diagnostic Cohort Study. J Pediatr. 2021 Nov;238:187-192.e2.
Murphy M, Shah V, Benzies K. Effectiveness of Alberta Family-Integrated Care on Neonatal Outcomes: A Cluster Randomized Controlled Trial. J Clin Med. 2021 Dec 14;10(24):5871. doi: 10.3390/jcm10245871. PMID: 34945163
2021
Mohamed A, Mohsen N, Diambomba Y, Lashin A, Louis D, Elsayed Y, Shah PS. Lung Ultrasound for Prediction of Bronchopulmonary Dysplasia in Extreme Preterm Neonates: A Prospective Diagnostic Cohort Study. J Pediatr. 2021 Nov;238:187-192.e2.
Murphy M, Shah V, Benzies K. Effectiveness of Alberta Family-Integrated Care on Neonatal Outcomes: A Cluster Randomized Controlled Trial. J Clin Med. 2021 Dec 14;10(24):5871. doi: 10.3390/jcm10245871. PMID: 34945163
2020
DiLabio J, Zwicker JG, Sherlock R, et al. Maternal age and long-term neurodevelopmental outcomes of preterm infants < 29 weeks gestational age [published online ahead of print, 2020 Jul 21]. J Perinatol. 2020;10.1038/s41372-020-0735-9. doi:10.1038/s41372-020-0735-9
Tamir Hostovsky L, Pan J, McNamara PJ, Belik J. Acetaminophen increases pulmonary and systemic vasomotor tone in the newborn rat. Pediatr Res. 2020;87(7):1171-1176. doi:10.1038/s41390-019-0725-9
Zozaya C, Shah J, Pierro A, et al. Neurodevelopmental and growth outcomes of extremely preterm infants with necrotizing enterocolitis or spontaneous intestinal perforation [published online ahead of print, 2020 May 15]. J Pediatr Surg. 2020;S0022-3468(20)30326-2. doi:10.1016/j.jpedsurg.2020.05.013
Goswami IR, Whyte H, Wintermark P, et al. Characteristics and short-term outcomes of neonates with mild hypoxic-ischemic encephalopathy treated with hypothermia. J Perinatol. 2020;40(2):275-283. doi:10.1038/s41372-019-0551-2
Shahroor M, Maarouf AM, Yang J, Yankanah R, Shah PS, Mohamed A. Complications Associated with Low Position versus Good Position Umbilical Venous Catheters in Neonates of ≤32 Weeks’ Gestation [published online ahead of print, 2020 Aug 9]. Am J Perinatol. 2020;10.1055/s-0040-1715117. doi:10.1055/s-0040-1715117
2019
Shahroor M, Lehtonen L, Lee SK, et al. Unit-Level Variations in Healthcare Professionals’ Availability for Preterm Neonates <29 Weeks’ Gestation: An International Survey. Neonatology. 2019;116(4):347-355. doi:10.1159/000501801
Castro M, Asbury M, Shama S, Stone D, Yoon EW, O’Connor DL, Unger S. Energy and Fat Intake for Preterm Infants Fed Donor Milk Is Significantly Impacted by Enteral Feeding Method. JPEN Journal of Parenteral and Enternal Nutrition. 2019 43(1):162-165.
Kharrat A, McNamara P, Weisz DE, Jain A. Merits and Perils of Targeted Neonatal Echocardiography-Based Hemodynamic Research: A Position Statement. Can J Physiol Pharmacol. 2019: 97(3):183-186.
Iwami H, Isayama T, Lodha A, Canning R, Abou Mehrem A, Lee SK, Synnes A, Shah PS. Canadian Neonatal Network and Canadian Neonatal Follow-Up Network Investigators. Outcomes after Neonatal Seizures in Infants Less Than 29 Weeks Gestation: A Population-Based Cohort Study. American Journal of Perinatology. 2019: 36(2):e1.
2018
Kang NY, Ivanovska J, Tamir-Hostovsky L, Belik J, Gauda EB. Chronic Intermittent Hypoxia in Premature Infants: The Link Between Low Fat Stores, Adiponectin Receptor Signaling and Lung Injury. Adv Exp Med Biol. 2018;1071:151-157. doi:10.1007/978-3-319-91137-3_19
Hodgson, K., Togo, A., Moore, A.M., Moody, A., King, S.K., Zani, A. Neonatal esophageal perforation: The role for nonoperative management. Journal of Paediatrics and Child Health. 2018: 54(8):872-874
Kasirer Y, Shah V, Yoon EW, Bromiker R, Mcnair C, Taddio A. Safety of fentanyl for peripherally inserted central catheter in non-intubated infants in the neonatal intensive care unit. Journal of Perinatology. 2018: 38(5):526-529
Kharrat A, Jain A. Guidelines for the management of acute unexpected cardiorespiratory deterioration in neonates with central venous lines in situ. Acta Paediatr. 2018: 107(11):2024-2025.
Mashally S, Nield LE, McNamara PJ, Martins FF, El-Khuffash A, Jain A, Weisz DE. Late oral acetaminophen versus immediate surgical ligation in preterm infants with persistent large patent ductus arteriosus. J Thorac Cardiovasc Surg. 2018: 156(5):1937-1944.
More KS, Sakhuja P, Giesinger R, Ting J, Keyzers M, Sheth J, Lapointe A, Jain A, Moore A, Miller S, McNamara P. Cardiovascular Associations with Abnormal Brain Magnetic Resonance Imaging in Neonates with Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia and Rewarming. American Journal of Perinatology. 2018: 35(10):979-989
Neary E, Jain A. Right ventricular congestion in preterm neonates with chronic pulmonary hypertension. Journal of Perinatology. 2018: 38(12):1708-1710.
Orlandi S, Raghuram K, Smith CR, Mansueto D, Church P, Shah V, Luther M, Chau T.Detection of atypical and typical infant movements using computer-based video analysis. Conf Proc IEEE Eng Med Biol Soc. 2018: 2018:3598-3601.
Papadhima I, Louis D, Purna J, Deshpande P, Diambomba Y, Lee S, Shah P, Weisz D, EL-Khuffash A, McNamara P, Mertens L, Jain A. Targeted Neonatal Echocardiography (TNE) Consult Service in a Large Tertiary Perinatal Center in Canada. Journal of Perinatology. 2018: 38(8):1039-1045
Raghuram K, Dunn M, Jangaard K, Reilly M, Asztalos E, Kelly E, Vincer M, Shah V. Inhaled corticosteroids in ventilated preterm neonates: a non-randomized dose-ranging study. BMC Pediatrics. 2018: 18(1):153.
Shah V, Hodgson K, Seshia M, Dunn M, Schmölzer GM. Golden hour management practices for infants <32 weeks gestational age in Canada. Paediatr Child Health. 2018: 23(4):e70-e76.
2018
Pediatric Academic Society (PAS)
Tamir Hostovsky, Liran; Ivanovska, Julijana; Belik, Jaques; Montandon,Gapard; Gauda, Estelle B. Leptin Stabilizes Breathing in Newborn Rat Pups without Effecting CO2 Chemosensitivity.
Rahde Bischoff, Adrianne; Pan, Jingyi; Belik, Jaques. Hydrogen peroxide, a potential prokinetic molecule, is present in higher concentration in infant formulas as compared with human breast milk.
Rahde Bischoff, Adrianne; McNamara, Patrick J.; Daneman, Alan; Ahyad, Rayan; Belik, Jaques. Exhibit Hall DE (Convention Center) Personalized feeding protocols for preterm neonates: The usefulness of gastric emptying rate measurements.
Rahde Bischoff, Adrianne; Kigozi, Phoebe; Al-Muttawa, Latifa; Benec, Joanna; Tomlinson, Christopher. Impact of lipid infusions on Intestinal Failure-Associated Liver Disease in infants born <1500g or undergoing GI surgery.
Rahde Bischoff, Adrianne; Dalle Molle, Roberta; Brondani Mucellini, Amanda3; Gaudreau, Hélène; Levitan, Robert5; Diorio, Josie4; Meaney, Michael; Silveira, Patrícia. Role of the accumbal μ-opioid receptors in the hedonic response to salt after intrauterine growth restriction in a rodent model and its correlates in children.
Estelle Gauda; Cindy Kang; Julijana Ivanovska; Jaques Belik; Liran Tamir-Hostovsky; Jingyi Pan. Developmental profile of adiponectin and adiponectin receptor expression in newborn rat lung during alveolarization.
Jessica Duby; Zohra Lassi; Zulfiqar Bhutta. Community-Based Antibiotic Delivery for Possible Serious Neonatal Bacterial Infections in Low and Middle Income Countries.
Stefani Doucette, Edmond Kelly, Paige Church, Shoo Lee, Vibhuti Shah and CNN. Utility of Inotropes in Preterm Infants <29 weeks GA and Neurodevelopmental Outcomes: A Retrospective Cohort Study.
Kamini Raghuram, Paige Church, Silvia Orlandi, Tom Chau, Maureen Luther, Vibhuti Shah. Automated Video-based Analysis of the General Movements Assessment for Infants at Risk of Motor Impairment.
Bonny Jasani, Fernando F Martins, Amish Jain, Dany Weisz, Regan, E Giesinger, Elaine Neary, Patrick J McNamara. Effect of Hemodynamically Significant Ductus Arteriosus on Doppler Flow Patterns of Pulmonary Veins in Preterm Infants.
Ashraf Kharrat, Patrick J McNamara, Dany E. Weisz, Ed Kelly, Edith Masse, Amit Mukerji, Deepak Louis, Jehier Afifi, Prakesh Shah, Amish Jain and CNN. Clinical burden of postnatally acquired acute critical illnesses among premature neonates in Canadian intensive care units.
Sumesh Thomas, Jessie van Dyk, Hussein Zein, Alberto Nettel Aguirre, Leonora Hendson, Selphee Tang, Paige Church, Rudaina Banihani, Elizabeth Asztalos. Split-week gestational age better predicts outcomes in preterm infants at the extremes of viability.
Vibhuti Shah, Eugene Ng, Eddy Lang, Rebecca Pillai Riddell, Denise Harrison, Thierry Lacaze-Masmonteil, Anna Taddio. Pain Management Strategies for Lumbar Puncture in Neonates: A Systematic Review.
Michelle Baczynski, Shannon Ginty, Dany Weisz, Patrick McNamara, Edmond Kelly, Prakesh Shah, Amish Jain. Outcomes of Hypoxic Respiratory Failure at Birth Associated with Previable Rupture of Membranes.
Joseph Ting, Ashley Roberts, Rebecca Sherlock, Cecil Ojah, Zenon Cieslak, Michael Dunn, Keith Barrington, Prakesh Shah. Prolonged initial empirical antibiotic use and neonatal outcomes in very-lowbirth- weight infants without cultureproven sepsis.
Ashraf Kharrat, Patrick McNamara, Dany Weisz, Edmond Kelly, Edith Masse, Amit Mukerji, Deepak Louis, Jehier Afifi, Prakesh Shah, Amish Jain. Clinical burden of postnatally acquired acute cardiopulmonary critical illness among preterm neonates of <32 weeks GA.
James Haiyang Xu, Helen Coo, Sandra Fucile, Eugene Ng, Joseph Ting, Prakesh Shah, Kimberly Dow. A national survey of enteral feeding practices in Canadian NICUs: Opportunities for improvement.
Elizabeth Stockley, Joseph Ting, John Kingdom, Sarah McDonald, Jon Barrett, Anne. Synnes, Luis Monterrosa, Prakesh. Shah. Antenatal Magnesium Sulphate for Fetuses with IUGR: Neonatal and Neurodevelopmental Outcomes.
Karel O’Brien, Anne Synnes, Julie Petrie, Ruth Grunau, Lucia Mirea, Xiang Ye, Paige Church. Utility of Inotropes in Preterm Infants <29 weeks GA and Neurodevelopmental Outcomes: A Retrospective Cohort Study.
Kamini Raghuram, Paige Church, Silvia Orlandi, Tom Chau, Maureen Luther, Vibhuti Shah. Automated Video-based Analysis of the General Movements Assessment for Infants at Risk of Motor Impairment.
Bonny jasani, Fernando Martins, Amish Jain, Dany Weisz, Regan Giesinger, Elaine Neary, Patrick McNamara. Effect of Hemodynamically Significant Ductus Arteriosus on Doppler Flow Patterns of Pulmonary Veins in Preterm Infants.
Student Papers
Each year the TCNH on-boards post-graduate students. Click below to read some of their original work
2023
Maria Casalino. Royal College of Surgeons in Ireland. Neonatal Intestinal Segmental Volvulus: What
Are the Differences with Midgut Volvulus? Supervisor: Dr. Estelle Gauda. May 2023
2020
Maria Casalino. Royal College of Surgeons in Ireland. The Presentation, Transmission and Outcomes of COVID-19 in Infants and Children. Supervisor: Dr. Estelle Gauda. May 2020