Completed Research

Completed Research

View by topic, some of the research recently completed at our hospitals.

Family Integrated Care


O’Brien K, Robson K, Bracht M, Cruz M, Lui K, Alvaro R, da Silva O, Monterrosa L, Narvey M, Ng E, Soraisham A, Ye XY, Mirea L, Tarnow-Mordi W, Lee SK; FICare Study Group and FICare Parent Advisory Board. Effectiveness of Family Integrated Care in neonatal intensive care units on infant and parent outcomes: a multicentre, multinational, cluster-randomised controlled trial. Lancet Child Adolesc Health. 2018 Apr;2(4):245-254. doi: 10.1016/S2352-4642(18)30039-7. Epub 2018 Feb 8. 

Haemodynamics


Krishnappa S, Shah PS, Jain A, Resende MHF, McNamara PJ, Weisz DEPredictors of Early Extubation after Patent Ductus Arteriosus Ligation among Infants Born Extremely Preterm Dependent on Mechanical Ventilation. J Pediatr. 2019 Nov;214:222-226.e3. doi: 10.1016/j.jpeds.2019.06.027. Epub 2019 Jul 3.

Giesinger RE, El Shahed AI, Castaldo MP, Breatnach CR, Chau V, Whyte HE, El-Khuffash A, Mertens L, McNamara PJ. Impaired Right Ventricular Performance is Associated with Adverse Outcome Following Hypoxic Ischemic Encephalopathy. Am J Respir Crit Care Med. 2019 Jun 28. doi: 10.1164/rccm.201903-0583OC.

Hébert A, Lavoie PM, Giesinger RE, Ting JY, Finan E, Singh Y, de Boode W, Kluckow M, Mertens L, McNamara PJ. Evolution of Training Guidelines for Echocardiography Performed by the Neonatologist: Toward Hemodynamic Consultation. J Am Soc Echocardiogr. 2019 Jun;32(6):785-790. doi: 10.1016/j.echo.2019.02.002. Epub 2019 Mar 26. No abstract available.

Kharrat A, Rios DI, Weisz DE, Giesinger RE, Groves A, Yang J, McNamara PJ, Shah PSJain A. The Relationship between blood pressure parameters and left ventricular output in neonates.   J Perinatol. 2019 May;39(5):619-625. doi: 10.1038/s41372-019-0337-6. Epub 2019 Feb 15.

Sakhuja P, More K, Ting JY, Sheth J, Lapointe A, Jain A, McNamara PJ, Moore AM. Gastrointestinal hemodynamic changes during therapeutic hypothermia and after rewarming in neonatal hypoxic-Ischemic encephalopathy. Pediatr Neonatol. 2019 Apr 16. pii: S1875-9572(18)30564-3. doi: 10.1016/j.pedneo.2019.04.003.

Papadhima I, Louis D, Purna J, Deshpande P, Diambomba Y, Lee S, Shah P, Weisz D, El-Khuffash A, McNamara PJ, Mertens L, Jain A. Targeted neonatal echocardiography (TNE) consult service in a large tertiary perinatal center in Canada. J Perinatol. 2018 Aug;38(8):1039-1045. doi: 10.1038/s41372-018-0130-y. Epub 2018 May 22.

Jain A, Mohamed A, Kavanagh B, Shah PS, Kuipers BCW, El-Khuffash A, Mertens L, Jankov RP, McNamara PJ. Cardiopulmonary Adaptation During First Day of Life in Human Neonates. J Pediatr. 2018 Sep;200:50-57.e2. doi: 10.1016/j.jpeds.2018.04.051. Epub 2018 May 24.

Neurodevelopmental Outcomes and Neonatal Follow-Up


Raghuram K, Isaac M, Yang J, AlAli A, Mireskandari K, Ly LG, Kelly E, Banihani R, Shah PS, Tehrani N. Neurodevelopmental outcomes in infants treated with intravitreal bevacizumab versus laser. J Perinatol. 2019 Sep;39(9):1300-1308. doi: 10.1038/s41372-019-0420-z. Epub 2019 Jul 24.

Lim JM, Porayette P, Marini D, Chau V, Au-Young SH, Saini A, Ly LG, Blaser S, Shroff M, Branson HM, Sananes R, Hickey EJ, Gaynor JW, Van Arsdell G, Miller SP, Seed M. Associations Between Age at Arterial Switch Operation, Brain Growth, and Development in Infants With Transposition of the Great Arteries. Circulation. 2019 Jun 11;139(24):2728-2738. doi: 10.1161/CIRCULATIONAHA.118.037495. Epub 2019 May 28.

Leijser LM, Miller SP, van Wezel-Meijler G, Brouwer AJ, Traubici J, van Haastert IC, Whyte HE, Groenendaal F, Kulkarni AV, Han KS, Woerdeman PA, Church PT, Kelly EN, van Straaten HLM, Ly LG, de Vries LS. Posthemorrhagic ventricular dilatation in preterm infants: When best to intervene? Neurology. 2018 Feb 20;90(8):e698-e706. doi: 10.1212/WNL.0000000000004984. Epub 2018 Jan 24.

Nutrition and Metabolics


Torgalkar R, Dave S, Shah J, Ostad N, Kotsopoulos K, Unger S, Shah PS. Multi-component lipid emulsion vs soy-based lipid emulsion for very low birth weight preterm neonates: A pre-post comparative study. J Perinatol. 2019 Aug;39(8):1118-1124. doi: 10.1038/s41372-019-0425-7. Epub 2019 Jun 24.

Asztalos EV, Campbell-Yeo M, da Silva OP, Ito S, Kiss A, Knoppert D; EMPOWER Study Collaborative Group. Enhancing breast milk production with Domperidone in mothers of preterm neonates (EMPOWER trial). J Hum Lact. 2017 Feb;33(1):181-187. doi: 10.1177/0890334416680176. Epub 2017 Jan 20. PubMed PMID: 28107101.

Jegathesan T, Bhutani VK, Campbell D, Shah V, Twiss J, Rasiah S, Baleswaran S, Antwi J, Prajapati D, Jhaveri A, Ehsan S, Visvanathaiyer, G, Sgro M. Effect of postnatal age and gestational age on total bilirubin rate of rise in moderate preterm infants. Paediatrics & Child Health, Volume 24, Issue Supplement_2, June 2019, Pages e55–e56,

Hoban R, Schoeny ME, Esquerra-Zwiers A, Kaenkumchorn TK, Casini G, Tobin G, Siegel AH, Patra K, Hamilton M, Wicks J, Meier P, Patel AL. Impact of Donor Milk on Short- and Long-Term Growth of Very Low Birth Weight Infants. Nutrients. 2019 Jan 22;11(2). pii: E241. doi: 10.3390/nu11020241.

Quality Improvement and Health Outcomes Research

 


 Zhong YJ, Claveau M, Yoon EW, Aziz K, Singhal N, Shah PS, Wintermark P; Canadian Neonatal Network (CNN) Investigators. Neonates with a 10-min Apgar score of zero: Outcomes by gestational age. Resuscitation. 2019 Oct;143:77-84. doi: 10.1016/j.resuscitation.2019.07.036. 

 Szigiato AA, Speckert M, Zielonka J, Hollamby K, Altomare F, Ng E, Nisenbaum R, Sgro M. Effect of Eye Masks on Neonatal Stress Following Dilated Retinal Examination: The MASK-ROP Randomized Clinical Trial. JAMA Ophthalmol. 2019 Sep 5. doi: 10.1001/jamaophthalmol.2019.3379.

Orkin J, Chan CY, Fayed N, Lin JLL, Major N, Lim A, Peebles ER, Moretti ME, Soscia J, Sultan R, Willan AR, Offringa M, Guttmann A, Bartlett L, Kanani R, Culbert E, Hardy-Brown K, Gordon M, Perlmutar M, Cohen E. Complex care for kids Ontario: protocol for a mixed-methods randomised controlled trial of a population-level care coordination initiative for children with medical complexity. BMJ Open. 2019 Aug 1;9(8):e028121. doi: 10.1136/bmjopen-2018-028121. Erratum in: BMJ Open. 2019 Sep 3;9(9):e028121corr1.

Butcher NJ, Tricco AC, Offringa M, Moher D, Galica J. Training researchers in publication science: why, what, and how. J Clin Epidemiol. 2019 Aug 27. pii: S0895-4356(19)30378-6. doi: 10.1016/j.jclinepi.2019.08.007.

Walker SAN, Cormier M, Elligsen M, Choudhury J, Rolnitsky A, Findlater C, Iaboni D. Development, evaluation and validation of a screening tool for late onset bacteremia in neonates – a pilot study. BMC Pediatr. 2019 Jul 24;19(1):253. doi: 10.1186/s12887-019-1633-1.

Kaempf JW, Morris M, Austin J, Steffen E, Wang L, Dunn M. Sustained quality improvement collaboration and composite morbidity reduction in extremely low gestational age newborns. Acta Paediatr. 2019 Jun 13. doi: 10.1111/apa.14895. 

Chatur N, Castro M, Young Tai KF. Macular Rash, Thrombocytopenia, and Hyperbilirubinemia in a Preterm Infant. Case Rep Pediatr. 2019 Apr 8;2019:4076740. doi: 10.1155/2019/4076740. eCollection 2019.

Nashid N, Khan S, Loutfy M, MacGillivray J, Yudin MH, Campbell DM, Barozzino T, Baqi M, Read SE, Bitnun A. Breastfeeding by Women Living With Human Immunodeficiency Virus in a Resource-Rich Setting: A Case Series of Maternal and Infant Management and Outcomes.  J Pediatric Infect Dis Soc. 2019 Feb 8. doi: 10.1093/jpids/piz003.

Downie ML, Cheema S, Campbell DM. An unusual case of hypovolemic shock in a neonate. Paediatr Child Health. 2018 Aug;23(5):303-305. doi: 10.1093/pch/pxx211. 

Rolnitsky AKirtsman M, Goldberg HR, Dunn M, Bell CM. The representation of vulnerable populations in quality improvement studies.Int J Qual Health Care. 2018 May 1;30(4):244-249. doi: 10.1093/intqhc/mzy016. Review.

Respiratory Health


Elshafei H, Ibrahim M, Montalva L, Machaly S, Young J, Zani A. Group B streptococcal sepsis and congenital diaphragmatic hernia: do not overlook normal initial imaging studies! Arch Dis Child Fetal Neonatal Ed. 2019 Sep;104(5):F540. doi: 10.1136/archdischild-2018-316667. Epub 2019 Mar 29. 

Kang NY, Ivanovska J, Tamir-Hostovsky L, Belik J, Gauda EB. Chronic Intermittent Hypoxia in Premature Infants: The Link Between Low Fat Stores, Adiponectin Receptor Signaling and Lung Injury.  Adv Exp Med Biol. 2018;1071:151-157. doi: 10.1007/978-3-319-91137-3_19.

Simulation


Chan NH, Mistry N, Campbell DM. A Simulation-Based Pilot Study of a Mobile Application (NRP Prompt) as a Cognitive Aid for Neonatal Resuscitation Training. Simul Healthc. 2019 Jun;14(3):146-156. doi: 10.1097/SIH.0000000000000353.

Petrosoniak A, Brydges R, Nemoy L, Campbell DM. Adapting form to function: can simulation serve our healthcare system and educational needs? Adv Simul (Lond). 2018 Jun 14;3:8. doi: 10.1186/s41077-018-0067-4.

Campbell DM, Poost-Foroosh L, Pavenski K, Contreras M, Alam F, Lee J, Houston P. Simulation as a toolkit-understanding the perils of blood transfusion in a complex health care environment.  Adv Simul (Lond). 2016 Dec 8;1:32. doi: 10.1186/s41077-016-0032-z.